Breakthrough CRISPR Technology Study Published in Nature … – Wire19

Benson Hill’s world-class scientists discover new mechanism for CRISPR technology that detects RNA

ST. LOUIS–(BUSINESS WIRE)– $BHIL #BHIL –A groundbreaking research study by a team that included researchers from Benson Hill , Inc. (NYSE: BHIL, the “Company” or “Benson Hill”), has been published this month in Character, the world’s leading multidisciplinary journal, highlighting a new mechanism with regard to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technologies. The research paper, titled “Cas12a2 elicits abortive infection via RNA-triggered destruction of dsDNA, ” discusses the discovery of a new enzymatic capability for CRISPR systems, opening the possibility of using CRISPR in new applications beyond gene editing – including cancer therapeutics, programmable shaping of microbial communities, and counterselection to enhance gene editing.

As part of its work to unlock the genetic diversity of plants, Benson Hill’s team collaborated with members of its Scientific Advisory Board, including university scientists from the U. S. and Germany, to uncover insights plus solve the complex biological problem regarding how CRISPR enzymes work. In doing so, they discovered the underlying biology and a brand new mechanism intended for how CRISPR nucleases, specifically Cas12a2, can function. The study concludes that will Cas12a2 holds substantial potential for CRISPR technologies as a biotechnological tool.

In a proof-of-principle demonstration, the research team showed that a specific amino acid sequence (SuCas12a2) can be repurposed for RNA detection plus potentially expand and enhance the CRISPR-based toolkit. More specifically, the study notes that will RNA targeted CRISPR activity could enable programmable killing of multiple cell types.

“At Benson Hill we recognize that it will take an entire community of innovators to solve the challenges of today. This is the great example of us partnering with the broader scientific community to better understand CRISPR technologies, ” said Gina Neumann, Senior Scientific Manager, Research and Development at Benson Hill. “It truly takes a diversity associated with thought plus approaches to unlock biology. I’m glad all of us could partner with fantastic academic collaborators to characterize this new enzymatic ability and lay a foundation for future innovative programs. ”

From the early days of Benson Hill, the particular company has taken a bold approach in order to learning how genetic variety can resolve problems and create brand new technologies.

In November 2022 Benson Hill formally endorsed the Framework for Responsible Use of Gene Editing in Agriculture . For Benson Slope, the precision of advanced breeding techniques like gene editing unlocks the opportunity to improve diverse crops and focus on benefits like taste, nutrition, plus sustainability to leverage the full power associated with plants and deliver better food choices to consumers.

The full study can be found online on Nature. com and in the Jan. 4 issue. Please refer to the particular Nature portfolio for the full research: .

About Benson Slope

Benson Hill moves food forward using the CropOS ® platform, the cutting-edge food innovation engine that combines data science and machine learning with biology plus genetics. Benson Hill empowers innovators in order to unlock nature’s genetic diversity from plant to plate, with all the purpose of creating nutritious, great-tasting food and ingredient options that are both widely accessible and sustainable. More information may be found at bensonhill. possuindo or on Twitter at @bensonhillinc.


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